IDH1 and neoplasm: In tumor cells, LncRNAs modify glycolysis and regulate HIF-1α expression [31], whereas in cervical cancer cells, lncRNA, IDH1-AS1, establishes an association of MYC proto-oncogene, BHLH transcription factor (c-MYC), and HIF-1 with mitochondrial respiration and glycolysis regulation via the actions of isocitrate dehydrogenase (NADP (+) 1 and cytoplasmic (IDH1) [32].