Transforming growth factor (TGF)-β plays a role in the invasion, metastasis and growth of cancer cells by promoting HDAC degradation and histone hyper-acetylation at the MEF2 site of the matrix metalloproteinase (MMP-10) promoter, and by activating MEF2A and up-regulating the expression of MMP-10 [103]. The gene discussed is MMP10; the disease is cancer.