While ANP32E, AURKB and BCL11A induce tumor progression in triple-negative breast cancer cells (Khaled et al., 2015; Xiong et al., 2018; Huang et al., 2019a), downregulation of CDK2-AP1 enhances tumor growth through cell cycle regulation (He et al., 2014). The gene discussed is CDK2; the disease is neoplasm.