TNXB and Ehlers-Danlos syndrome due to tenascin-X deficiency: Tnxb−/− mice also exhibited gastric dysfunction associated with accelerated gastric emptying and hypersensitivity of gastric vagal mechanoreceptors (Figure 1B) (Aktar et al., 2019), which are consistent with TNX-related clEDS patients (Schalkwijk et al., 2001; Lindor and Bristow, 2005).