TNXB and cutaneous melanoma: In conjunction with a tumor suppressor role of TNX, the expression of TNX was shown to be downregulated in most tumor tissues such as the lung, breast, prostate, colon, stomach, liver, kidney, skin melanoma, and leiomyoma by using in silico large database studies of the Gene Expression Omnibus (GEO) and The Cancer Genomic Atlas (TCGA) (Liot et al., 2020), although there are some discrepancies in the expression pattern of TNX in glioma and ovarian cancer compared with those of previous published data (Hasegawa et al., 1997; Kramer et al., 2015).