These results indicated that pain in both TNX-related clEDS and COL5A1-related classical EDS corresponds to neuropathic pain associated with hypersensitization of myelinated Aδ- and Aβ-fibers, disorganization of Nav1.8-expressing fibers, and central sensitization of the spinal cord. The gene discussed is COL5A1; the disease is Ehlers-Danlos syndrome.