High transcriptional levels of the 12 key genes (ANLN, CDKN3, KIF4A, CEP55, CCNB1, KIF11, CCNB2, MELK, HMMR, ASPM, CENPF, and BUB1) were all significantly related to poorer OS (all p < 0.001) and FP survival (all p < 0.01) in NSCLC. The gene discussed is HMMR; the disease is non-small cell lung carcinoma.