PPAR-α mainly plays a role in removing circulating lipids or cell lipids, PPAR-β is involved in lipid oxidation and cell proliferation, while PPAR-γ activation enhances the proliferation of cancer cells and promotes brain metastasis (Bougarne et al., 2018; Magadum and Engel, 2018; Zou et al., 2019). This evidence concerns the gene PPARD and cancer.