The UBE2S protein plays an oncogenic role in various tumors, including urinary bladder cancer (Tang et al., 2021), breast cancer (Ayesha et al., 2016), endometrial cancer (Lin et al., 2019), ovarian cancer (Hu et al., 2021), lung cancer (Liu and Xu, 2018; Qin et al., 2020), colorectal cancer (Li et al., 2018), hepatocellular carcinoma (Gui et al., 2021), and melanoma (Wang et al., 2021), via the activation of the mTOR pathway (Tang et al., 2021), SOX6/β-Catenin signaling pathway (Lin et al., 2019), and Wnt/β-catenin signaling pathway (Qin et al., 2020; Hu et al., 2021). The gene discussed is UBE2S; the disease is melanoma.