PCa patients in the high-risk group had higher IPS scores (PD-1 negative and CTLA-4 negative), significantly correlated with immune checkpoint blockade-related genes (i.e., TNFRSF4, TNFRSF14, TNFRSF18, and TNFRSF25). This evidence concerns the gene TNFRSF4 and posterior cortical atrophy.