WNK2 and viral infectious disease: RPSA also plays a role in regulating the mitogen-activated protein kinase (MAPK) signaling pathway (Givant-Horwitz et al., 2004), and many viral infections have been associated with deviations from well-balanced control of the MAPK signaling cascade, such as Ebola virus (Strong et al., 2008) and influenza A virus (Mizumura et al., 2003).