Similarly, MetS samples expressing six central genes (STOM, BATF, CASP4, MT1F, CFLAR, UROD) showed positive correlations in glycolysis, oxidative phosphorylation and fatty acid metabolism pathways (Figure 5F), while MAP3K14 expression was negatively correlated with glycolysis, oxidative phosphorylation and fatty acid metabolism (Figure 5F). The gene discussed is CASP4; the disease is metabolic syndrome.