This is a low minor allele frequency (MAF) based on the NCBI database [A = 0.000004/1 (GnomA Dexomes)], but some investigators have found a polymorphism of MAD2L1 rs1283639804 in combination with the polymorphism of MAD1L1 rs1801368 conferring colorectal and lung cancers (Guo et al., 2010; Zhong et al., 2015). Here, MAD1L1 is linked to lung cancer.