Li, H. et al. (2020) showed that ROC curve of SAA in predicting COVID-19 progression had an AUC of 0.856 with a cut-off value of 159 mg/L (53).Surprisingly, Zhang, J. et al. (2020) showed no significant difference in the SAA level between severe and non-severe groups (47), but there were no critically ill patients included in that study. The gene discussed is SAA1; the disease is COVID-19.