Genes encoding proteases for extracellular matrix degradation, like matrix metalloprotease family members (MMP9 and MMP13, log2FoldChange = 6.32 and 4.64, respectively)11 and KLK10 (log2FoldChange = 4.74),12 were among the top upregulated genes in the PDAC tumor tissues. This evidence concerns the gene MMP9 and neoplasm.