Restore MIA-induced weight loss in dams, social deficits, repetitive and stereotyped behaviors, depression-like behaviors, and anxiety-like behaviors in adult offspring; parvalbumin positive neuron loss; the decrease in levels of GABA in the PFC of adult offspring, and the decrease in proinflammatory cytokines (IL-6 and IL-17a) in both the maternal serum and fetal brain. The gene discussed is PVALB; the disease is depressive disorder.