Gender, educational level, occupation, marital status, DM duration, frequency of follow-up, and visiting a diabetic educator were significantly associated with knowledge of insulin use, as lower mean knowledge scores were noted among females, uneducated subjects, homemakers, those with DM for 10 years or less, with insulin therapy for five years or less, having followed up monthly, and not seeing diabetic educator. The gene discussed is INS; the disease is diabetes mellitus.