ACE and angina pectoris: A likely reason is the high incidence of atherosclerotic irregularities in patients with up to intermediate epicardial stenoses [18]. Each plaque, depending mainly on the degree of infiltration with macrophages, can be a source of angiotensin-converting enzyme and high local levels of angiotensin II, therefore creating a risk of coronary spasm under stress [19]. The therapy with β-blocker as the only vasoactive angina medication was higher (although insignificantly) than the other two vasoactive therapeutic combinations.