Interleukin-1beta (IL-1β), interleukin-4 (IL-4), interferon-gamma (IFN-γ), transforming growth factor beta (TGF-β) released by tuberculosis patients' peripheral blood mononuclear cells in in vitro research studies as well as the research that examined the amounts of TNF-α in BAL fluid demonstrated that more the lung involvement present, higher the cytokine production [15,16]. This evidence concerns the gene TNF and tuberculosis.