In endometrial cancer, FTO catalyzes the demethylation of the 3’UTR region of HOXB13 mRNA, which reduces the decay of mRNA associated with the recognition of m6A modification of YTHDF2 protein and increases the expression of HOXB13 protein, accompanied by the activation of the WNT signaling pathway and the expression of downstream proteins, leading to tumor metastasis and invasion (208). This evidence concerns the gene FTO and neoplasm.