Moreover, overexpression of ALKBH5 exerts tumor suppressive effects in pancreatic ductal adenocarcinoma (PDAC) by reducing WIF1 mRNA methylation and regulating the Wnt pathway, leading to downregulation of C-MYC, Cyclin D1, MMP-2, and MMP-9 and sensitizing PDAC cells to gemcitabine (180). This evidence concerns the gene ALKBH5 and neoplasm.