In a previous study in 2021, 3D-cultured cells from leiomyosarcoma and undifferentiated pleomorphic sarcoma (UPS) surgical specimens were treated with trabectedin and demonstrated the involvement of ECM-associated genes such as mmps and their inhibitor timp1, emphasizing the potential role of ECM in the activity of trabectedin (10). The gene discussed is TIMP1; the disease is undifferentiated pleomorphic sarcoma.