SMC4 and neoplasm: SMC4 protein, as a sensitive switch of the condensin complex, which combines with SMC2 monomer to form a V-shaped structure, and then combines with other non-SMC subunits to form the condensin complex, plays a highly crucial role in the process, including DNA repair and correct compression and dissociation of sister chromatids; therefore SMC4 is inextricably related to the occurrence and development of tumor.