Through real-time polymerase chain reaction (PCR), Western blot, immunohistochemistry (IHC), and other experimental results, SMC4 expression has been confirmed up-regulated in HCC tissues, and the expression level of SMC4 in HCC tissues was associated with tumor size, TNM stage, cell differentiation, and vascular invasion, indicating that the expression level of SMC4 is related to the poor prognosis of patients with hepatoma (16). This evidence concerns the gene SMC4 and hepatocellular carcinoma.