SMC4 and hepatocellular carcinoma: Moreover, research also found that under hypoxic culture, through HIF-1-miR-219-SMC4 regulatory pathway suppression of SMC4 could inhibit the proliferation rate of hepatocellular carcinoma (HCC) cells through inducing G1 phase arrest and affecting cell migration ability by affecting the process of epithelial-to-mesenchymal transition (EMT) (18).