SMC4 and neoplasm: first observed that SMC4 was associated with immune cell infiltration in the tumor microenvironment (TME) of PA using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, where its mechanism may be related to that immune cell infiltration, and secretion of cytokine promote the formation of the TME in PA, thus facilitating tumor progression, metastasis, and therapeutic resistance (33).