established a first nomogram to identify EGC patients at high risk for LNM using preoperative indicators, the model incorporated 6 independent predictors including tumor size, gross features, histological differentiation, P53, CA19-9, and lymph node status reported by computed tomography, the model has a C-index of 0.82 (95% CI: 0.78-0.86), which has a high clinical value (22), but due to the relatively small number of included studies. The gene discussed is TP53; the disease is neoplasm.