The risk score was calculated based on the expression levels of five genes: HOOK1, LGR5, HOXC6, CKMT2, and SPINK4. HOOK1 expression is related to histologic variants, the maximum tumor diameter, and intrathyroidal dissemination in patients with thyroid carcinoma (47). The gene discussed is HOXC6; the disease is thyroid gland carcinoma.