CHD7 and dilated cardiomyopathy: Figure 2D shows the correlation between CRG clusters, clinical characteristics, and CRG expression in patients with COAD. Gene Set Variation Analysis showed that CRG cluster A was significantly enriched in immune-related pathways, including neuroactive ligand receptor interaction, glycosaminoglycan degradation, glycosaminoglycan biosynthesis chondroitin sulfate, and dilated cardiomyopathy (Figure 2E).