Factors, such as AFP ≥ 400 ng/mL, GGT > 60 U/L, VEGF-A among 127.8 to 240.3 pg/mL, VEGF-A > 240.3 pg/mL, peritumoral enhancement, unclear peritumoral boundary, irregular tumor shape, tumor size > 50 mm, MVI-positive, microscopic portal vein thrombus, intratumor necrosis, capsular invasion, surgical margin among 5.0 to 10.0 mm and surgical margin < 5.0 mm were found to be the possible predictors for recurrence of HCC by univariate analysis. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.