TP53 and cancer: In recent studies, ITGB1 was not only able to promote tumor progression by participating in multiple tumor-related signaling pathways such as p53 (63), EMT (34), and PI3K/AKT (20, 64), which regulate the expression of proto-oncogenes or suppressors but also serve as important biomarkers to assess the prognosis of cancer patients (33, 65).