It has been demonstrated that ENO1 mediates crosstalk between ENO1high and ENO1low HCC cells in an exosome-dependent manner and promotes the proliferation and metastasis of ENO1low HCC cells by upregulating integrin α6β4 expression and activating the FAK/Src-p38MAPK pathway, similarly in ENO1high HCC cells (153). The gene discussed is ENO1; the disease is hepatocellular carcinoma.