found a novel mechanism of M-MDSC motility that MMP14 regulated by CXCL10/TLR4 mediates M-MDSCs enrichment in liver graft, which promotes HCC recurrence after transplantation (107). Whereas it was found that blocking HSCs-induced intrinsic p38 MAPK signaling in monocytes inhibited the formation of MDSCs and their enrichment in fibrotic liver, which effectively inhibited HCC growth (104). The gene discussed is CXCL10; the disease is hepatocellular carcinoma.