found a novel mechanism of M-MDSC motility that MMP14 regulated by CXCL10/TLR4 mediates M-MDSCs enrichment in liver graft, which promotes HCC recurrence after transplantation (107). Whereas it was found that blocking HSCs-induced intrinsic p38 MAPK signaling in monocytes inhibited the formation of MDSCs and their enrichment in fibrotic liver, which effectively inhibited HCC growth (104). This evidence concerns the gene TLR4 and hepatocellular carcinoma.