With persistent hypoxia, HCC cells-derived necrotic debris was reported to induce TAMs to secrete potent IL-1β through the TLR4/TIR domain-containing adapter-inducing interferon-β (TRIF)/NF-κB pathway, which promoted HCC cells EMT and immune evasion (130). The gene discussed is TLR4; the disease is hepatocellular carcinoma.