Similarly, exosomal miR-1247-3p derived from high-metastatic HCC cells (HMHs) in the lung metastatic niche reportedly triggered and stimulated β1-integrin/NF-κB signaling pathway in fibroblasts by directly targeting beta 1,4-galactosyltransferase, polypeptide 3 (B4GALT3) and activated CAFs in turn accelerated the development of HCC via producing IL-6 and IL-8 (77). This evidence concerns the gene IL6 and hepatocellular carcinoma.