A recent study reported that the palmitoylation of hexokinase 1 (HK1) is induced in HSCs after stimulated by TGF-β, thus more HK1 is secreted by forming large extracellular vesicles, which can be absorbed by HCC cells, causing enhanced glycolysis and HCC development (78). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.