IDH1 and neoplasm: All these methods include genotyping for known tumor mutations using PCR-based approaches, such as isocitrate dehydrogenase 1 or 2 (IDH1/2) aberrations (79); mass spectroscopy based on defined tumor spectral profiles, which is similar to magnetic resonance spectroscopy techniques (80); All these methods need to be further tested for specificity and sensitivity in resectioning gliomas.