BRCA1 and ovarian cancer: We, thus, isolated olaparib resistant clones from three cell lines; SUM159-KO1 and SUM159-KO2, two CRISPR BRCA1 knock out clones we engineered from the TNBC SUM159 cell line, the SUM149 TNBC cell line which bears a frameshift mutation in exon 11 (2288delT) (57) and the UWB1.289 ovarian cancer cell line also showing a frameshift mutation in exon 11 (2594delC) (58).