Long noncoding RNA homeobox (HOX) A11 antisense lncRNA (HOXA11-AS) was discovered to bind to transcription factor WD repeat domain 5 (WDR5) in the promoter region, promote -catenin transcription, and activate the Wingless-Type MMTV Integration Site Family (WNT) signaling pathway, accelerating cancer metastasis in vivo. This evidence concerns the gene WDR5 and cancer.