The lncRNA HOTAIR can affect the co-localization and activity of vesicle-associated membrane protein 3 (VAMP3) and synaptosomal-associated protein 23 (SNAP23) to promote the fusion of MVB with the plasma membrane to promote HCC exosome secretion, confirming that lncRNAs have the function of promoting cancer exosome secretion and providing a new idea for the study of cancer lncRNAs (Figure 3). Here, VAMP3 is linked to cancer.