Their study confirmed that in SF3B1 mutant MDS, down-regulation of ABCB7 and TMEM14C expression could exert synergistic effects to induce significant up-regulation of ferritin in mitochondria, disrupting the sequence of heme synthesis (46) and reducing the erythrocyte set-up capacity of normal bone marrow cells (47), leading to the formation of RS. Here, TMEM14C is linked to myelodysplastic syndrome.