Therefore,Combined with the topmost Pearson coefficient between LSM5 and 8, we preliminarily proposed that there may be the existence of LSM5 and LSM8 complex that played a role in GC chemoresistance.We then investigated KEGG analysis of LSM5, LSM8 and related genes and found that positive regulation of canonical Wnt signaling pathway and regulation of stem cell differentiation were significant. The gene discussed is LSM5; the disease is gastric cancer.