Once in the bone, tumor cells promote the secretion of various cytokines such as RANKL, Vascular endothelial growth factor (VEGF), Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-11 (IL-11) and Tumor necrosis factor-α (TNF-α) directly or indirectly, which induces the formation and maturation of osteoclasts resulting in massive bone absorption, which provides favorable conditions for tumor cell colonization (8). Here, TNF is linked to neoplasm.