The expression level of SLC7A11 in biopsy tissues and glioma cell lines of patients with glioblastoma was higher than that in normal brain tissues (112); therefore, inhibition of system XC- or the GPx4 system by a FIN can enhance the RT effect in sarcoma, breast cancer and glioblastoma (113). This evidence concerns the gene SLC7A11 and glioblastoma.