The mRNA expression of DDR1 in SK-HEP is similar to that in the LX2 cell. Down-regulation of DDR1 decreases the phosphorylation of AKT and ERK, inhibits the expression of ICAM1, Ki67, VCAM1, and MMP9, reduces the adhesion and migration of HCC cells to collagen type I. This evidence concerns the gene MMP9 and hepatocellular carcinoma.