DDR1 is highly expressed in metastatic hepatic tissue from CRC and is associated with poor prognosis. In the three CRC cell lines, the functional DDR1 (phosphorylated DDR1) increased by 1.5-fold compared with those in basal conditions. LSECs- and HSCs-derived secretomes increase DDR1 phosphorylation and MMP2 secretion in CRC cells. Silencing of DDR1 in C26 cells significantly reduces the expression of collagen and MMP2, migratory ability, and metastatic growth in the liver. This evidence concerns the gene DDR1 and colorectal carcinoma.