Rhynchophylline has been shown to activate the cAMP signaling pathway and MAPK/NF-κB signaling pathway to exert neurotransmitter modulation, anti-inflammatory, antioxidant, sedative, anti-Alzheimer’s disease, and anti-drug addiction effects (Geetha and Ramachandran, 2021; Qin et al., 2021). This evidence concerns the gene NFKB1 and early-onset autosomal dominant Alzheimer disease.