MPH increased attention and memory capacity and decreased impulsivity in SHRs (Leffa et al., 2019), and altered the expression of genes associated with impulse characteristics, such as nuclear receptor 4a2 (NR4A2), B-cell translocation gene 2 (Btg2), and Homer2 (Dela Peña et al., 2017), indicating that SHRs showed a positive response to neurostimulants and can better predict ADHD-related pathological mechanisms. This evidence concerns the gene BTG2 and attention deficit-hyperactivity disorder.