Further studies have found that in DU145 and PC-3 prostate cancer cells, menthol inhibits cell motility by inhibiting the phosphorylation of protein tyrosine kinase 2 (PTK2) through the TRMP8 pathway (Yang et al., 2009; Zhu et al., 2011; Wang et al., 2012). The gene discussed is PTK2; the disease is prostate cancer.