Compared with unmodified MSCs, BM-MSCs overexpressing Ang-1 reduced BALF neutrophil and total cell counts, levels of inflammation-related mediators (IFN-γ, IL-1β, IL-6, and TNF-α), MPO activity, and alveolar proteinaceous exudate in experimental LPS-induced ARDS (Mei et al., 2007; Xu et al., 2008). This evidence concerns the gene MPO and acute respiratory distress syndrome.