NFE2L2 and Alzheimer disease: In AD-MSCs, long-term exposure to a low dose (10 μM) of H2O2 led to increased survival by upregulating nuclear factor-erythroid 2-related factor 2 (Nrf2) and several anti-oxidant mediators (catalase, glutathione peroxidase-1, heme oxygenase (HO)-1 and SOD) but reduced intracellular ROS levels and expression of Cox-2 and IL-1β (Garrido-Pascual et al., 2020).