In experimental LPS-induced ARDS, BM-MSCs overexpressing ACE2 were also more effective than unmodified MSCs, resulting in a greater reduction in lung injury, vascular permeability, BALF neutrophil counts, IL-1β and IL-6 levels, but increased levels of lung IL-10 and eNOS (He et al., 2015). Here, IL1B is linked to acute respiratory distress syndrome.