On the other hand, AD-MSCs underwent apoptosis by serum depletion, but were shown to increase levels of anti-oxidant factors (glutathione peroxidase and HO-1) and reduce levels of inflammation-related mediators (IL-1β, MIP-1α, and TNF-α), yielding attenuated lung and heart injury and an improved survival rate in experimental cecal ligation and puncture (CLP)-induced sepsis (Chang et al., 2012; Chen et al., 2014). This evidence concerns the gene TNF and Sepsis.