The potential mechanisms were found to be mainly involved in phosphoinositide 3-kinase (PI3K)-Akt, JAK2, MAPK, protein tyrosine phosphatase non-receptor type 1 (PTPN1) signaling pathway, neuroactive ligand-receptor interaction, as well as fluid shear stress and atherosclerosis (Liu et al., 2020; Zhang et al., 2020). This evidence concerns the gene PTPN1 and atherosclerosis.