Moreover, the induction of type 1 diabetes in C57BL/6J mice with STZ results in urinary albumin excretion and renal dysfunction, as well as renal enlargement, increased glomerular mesangial matrix, progressive glomerulosclerosis, and upregulation of TGF–β and vascular endothelial growth factor (VEGF) expression. The gene discussed is VEGFA; the disease is type 1 diabetes mellitus.