Serum albumin becomes insoluble and aggregates during co–incubation with methylglyoxal, glycolaldehyde (Naftaly et al., 2021) and ribose–modified albumin, thereby forming amyloid–like aggregates that induce cytotoxicity (Wei et al., 2009), which is linked to the development of Alzheimer’s disease (Tu et al., 2016). This evidence concerns the gene ALB and early-onset autosomal dominant Alzheimer disease.