APOB and metabolic dysfunction-associated steatotic liver disease: APOB (apolipoprotein B)-oriented LDs (Ohsaki et al., 2006) and bortezomib-induced Mallory Denk bodies (MDBs) in liver cells (Strnad et al., 2008; Harada et al., 2008; Harada, 2010) can be eliminated by lipophagy, suggesting that lipophagy can protect against NAFLD development.