For example, it has been found that polydatin promotes mitochondrial biogenesis and protects against mitochondrial oxidative stress via the activation of Sirtuin-1-PGC-1α pathway and Sirtuin-1-Nrf2-ARE pathway in kidney diseases (Huang et al., 2015; Zeng et al., 2016; Chen and Lan, 2017; Gao et al., 2020b). This evidence concerns the gene NFE2L2 and kidney disorder.