Studies have found that resveratrol can upregulate the expression of mitochondrial ROS scavenging enzymes, and attenuate mitochondrial oxidative stress via the activation of Nrf2 pathway and Sirtuin-3-FoxO3a pathway in AKI and CKD models (Xu et al., 2012; Wang et al., 2015b; Fu et al., 2017; Kim et al., 2018; Wang et al., 2018; Rahman et al., 2022). This evidence concerns the gene NFE2L2 and acute kidney injury.