In recent years, many studies have confirmed that HIF-1α is closely related to the occurrence and development of inflammation and plays a strong pro-inflammatory role in the pathogenesis of rheumatoid arthritis, psoriasis, pulmonary hypertension, and tumors (Kriebel et al., 2018; Luo et al., 2019; Zhang et al., 2020; Zhu et al., 2020). This evidence concerns the gene HIF1A and rheumatoid arthritis.