Ran Zhang et al. found that knocking down G protein-coupled receptor 30 (GPR30) in CAFs reduced CXCL12 expression and thus inhibited macrophage migration, as well as that macrophages had attenuated M2 polarization, downregulated M2-like marker expression, and inhibited prostate cancer (PCa) cell invasion by reducing IL-6 secretion (Zhang et al., 2021). The gene discussed is GPER1; the disease is Familial prostate cancer.