In addition to the regulatory molecules mentioned above, inflammatory cytokines in TME such as chemokines (CXL), interleukins (IL), interferons (IFN), and tumor necrosis factors (TNF) not only govern CAF activation but also directly or indirectly promote tumor growth (Rollins, 2006; Mhaidly and Mechta-Grigoriou, 2020). Here, TNF is linked to neoplasm.