HGF and neoplasm: Myristoylated alanine-rich protein kinase C substrate (MARCKS), the forkhead box F1 gene (FoxF1), and the zinc finger transcription factor (snail 1) by activating AKT/Twist1 signaling to upregulate αSMA and PDGFR, the release of paracrine factors such as FGF-2 and HGF is promoted, resulting in the activation of CAFs and tumor (Saito et al., 2010; Stanisavljevic et al., 2015; Yang et al., 2016a).