For example, pCAFs (Cancer-promoting CAFs) inhibit antitumor immunity mainly by expressing FAP-α or a-SMA multiplex, while rCAFs (Cancer-restraining CAFs) inhibit pancreatic cancer growth with Meflin (glycosylphosphatidylinositol-anchored protein) as a biomarker (Takahashi et al., 2021). Here, SMN1 is linked to cancer.