For instance, CXCL12 generation by activated CAF in PDAC increases migration of peripheral CD8+ T cells to active CAF in the peritumor stromal region, resulting in a concentration of CD8+ T cells in the pan-mesenchymal compartment and decreased recruitment to the tumor islets (Ene-Obong et al., 2013). Here, CXCL12 is linked to neoplasm.