The results of the study showed that CAF increased the expression and activity of 5-lipoxygenase (5-LO) in MDSCs by secreting IL-6 and IL-33, which greatly contributed to the efficiency of tumor sphere formation and stemness marker gene expression in intrahepatic cholangiocarcinoma (ICC) cells (Lin et al., 2022). This evidence concerns the gene ALOX5 and intrahepatic cholangiocarcinoma.