The results of the study showed that CAF increased the expression and activity of 5-lipoxygenase (5-LO) in MDSCs by secreting IL-6 and IL-33, which greatly contributed to the efficiency of tumor sphere formation and stemness marker gene expression in intrahepatic cholangiocarcinoma (ICC) cells (Lin et al., 2022). The gene discussed is IL33; the disease is intrahepatic cholangiocarcinoma.