TFRC and brain neoplasm: Most commonly expressed receptor on brain are low density lipoprotein receptor (LDL-R), apolipoprotein E (ApoE) receptor, EGFR, transferrin receptor (TfR), insulin receptor (IR) and integrin receptor (αvβ3) and can be employed efficiently to promote drugs and diagnostic agents into the brain for brain tumor treatment and imaging respectively (Yeini et al., 2021).