Figure 2 shows that MPO activity (Figure 2A), pro-inflammation cytokine TNF-α/IL-6 (Figures 2B, C) production in colonic tissues, and FD-4 levels (Figure 2D) in serum samples from colitis mice were significantly higher than those from normal mice; these effects could be reversed by kumatakenin or SASP. The gene discussed is TNF; the disease is colitis.