Ahn et al. (38) reported a significant relationship between rs3829251 and 25OHD (p = 8.8 × 10−7), and our colocalization analyses inferred that rs3829251, which is located in the 7-dehydrocholesterol reductase gene, might impact the concentration of human 25OHD by regulating the expression of NADSYN1/DHCR7, consequently reducing COPD risk. This evidence concerns the gene NADSYN1 and chronic obstructive pulmonary disease.