DDIT4 and hepatocellular carcinoma: Among them, miR-221 was evidenced to promote hepatcarcinogenesis by dysregulating DNA damage-inducible transcript 4 (DDIT4), the modulator of mTOR pathway, whereas miR-101 that is downregulated in HCC may induce apoptosis and inhibit tumorigenicity via targeting Mcl-1 (Su et al., 2009; Pineau et al., 2010).