AFP and Cirrhosis: After validated to be in plasma-derived exosomes from HBV/HCV-infected non-HCC, such as chronic hepatitis and cirrhosis, and HCC samples, four miRNAs including miR-10b-5p, miR-221-3p, miR-223-3p and miR-21-5p were identified as novel potential biomarkers for early HCC diagnosis, and their combination showed better sensitivity in distinguishing HCC, especially with low AFP expression.