Julich-Haertel H et al. isolated and detected various tumor-associated EV populations from patient serum and plasma via Fluorescence-activated cell scanning (FACS), and found that AnnexinV+ EpCAM+ ASGPR1+ EV and AnnV+ CD44v6+ EV were excellent in distinguishing liver malignancies from cirrhotic/control subjects (Julich-Haertel et al., 2017; Urban et al., 2020). The gene discussed is ANXA5; the disease is neoplasm.