Through a series of studies, Abd El Gwad A et al. demonstrated the role of three EV RNA-based biomarkers (lncRNA-RP11-513I15.6, miR-1262 and RAB11A) in inducing the formation of precancerous lesions in rats, and their excellent ability to differentiate HCC patients from chronic hepatitis and healthy volunteers (Abd El Gwad et al., 2018; Matboli et al., 2019; Hasanin et al., 2020). This evidence concerns the gene RAB11A and chronic hepatitis.