The hnRPH1 gene encodes a splicing regulator that can stimulate pre-mRNA cleavage and polyadenylation, and is abnormally expressed in a number of human cancers such as esophageal cancer, pancreatic cancer, colon cancer, and prostate cancer (Honoré et al., 2004; Sun et al., 2016; Yang et al., 2016). This evidence concerns the gene HNRNPH1 and esophageal cancer.