Recent studies revealed that LC3B+ EVs carrying HSP90α are the master regulators of tumor progression, and the level of plasma HSP90α+ LC3B+ EVs in HCC patients were significantly higher than those in non-cancerous controls, suggesting the potential role as a diagnostic marker for HCC(Chen Y. Q. et al., 2022). The gene discussed is HSP90AA1; the disease is hepatocellular carcinoma.