TRPA1 and Arthritis: In most arthritis studies, TRPA1 was reported to be increased and acted as a promoter of joint destruction, mediating inflammatory and catabolic effects (Nummenmaa et al., 2016), oxidative stress (Phull et al., 2018), apoptosis (Yin et al., 2018), edema, and pain (Garrison and Stucky, 2014).