Furthermore, the suppression of TRPA1 by its antagonist HC-030031 or TRPA1 gene knockout ameliorates the chondrogenic phenotype of CH and prevents OA (Moilanen et al., 2015a; Moilanen et al., 2015b; Nummenmaa et al., 2016). Here, TRPA1 is linked to cyclic hematopoiesis.