TRPA1 and cyclic hematopoiesis: The limitations of this study are as follows: 1) we only used the AITC to imitate the activation of TRPA1 in OA, but the dysfunction of TRPA1 was not tested and discussed, which would not cover the full mechanism of how TRPA1 influences the CH phenotype and OA process; 2) the AITC was also reported to have antioxidant (Caglayan et al., 2019) and bactericidal activity (Lin et al., 2000), which were not tested but may also protect the CH phenotype; 3) the methodological approach was not diversified.