Medulloblastoma, a well-known cilia-related cancer, is an embryonal malignant tumor that predominantly affects children and is now histopathologically classified into five major types: Wnt-activated; SHH-activated and TP53-mutated; SHH-activated and TP53 wild type; non-Wnt/non-SHH type; and histologically defined type, which contains classic medulloblastoma, desmoplastic/nodular medulloblastoma, medulloblastoma with extensive nodularity, and large cell/anaplastic medulloblastoma (WHO Classification of Tumours Editorial Board, 2021). The gene discussed is TP53; the disease is medulloblastoma with extensive nodularity.