A study reported that stroke was associated with cognitive impairment and dementia in older adults, and the six RNA-binding protein (RBP) genes (POLR2F, DYNC1H1, SMAD9, TRIM21, BRCA1, and ERI1) might participate in the process by mediating the hypoxic responses and angiogenesis (33). The gene discussed is TRIM21; the disease is Cognitive impairment.