A study reported that stroke was associated with cognitive impairment and dementia in older adults, and the six RNA-binding protein (RBP) genes (POLR2F, DYNC1H1, SMAD9, TRIM21, BRCA1, and ERI1) might participate in the process by mediating the hypoxic responses and angiogenesis (33). This evidence concerns the gene TRIM21 and dementia.