Point mutations in charged multivesicular body protein 2B (CHMP2B), valosin containing protein (VCP), ubiquilin 2 (UBQLN2), optineurin (OPTN), cyclin F (CCNF), TANK binding kinase 1 (TBK1), and sequestosome 1 (SQSTM1/p62), have been causally implicated in ALS-FTD pathology (Renton et al., 2014; Oakes et al., 2017; Rayner et al., 2021; Chua et al., 2022). The gene discussed is UBQLN2; the disease is frontotemporal dementia.