Furthermore, histone deacetylase 6 (HDAC6) has a relevant role in the process of fusion between autophagosomes and lysosomes and its therapeutical effect has been tested in animal models of superoxide dismutase 1 (SOD1)-linked ALS, where its genetic inhibition prolonged the lifespan of the animals (Taes et al., 2013). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.