The finding that most patients suffering from ALS-FTD do not harbor mutations in TARDBP gene, yet present cytoplasmic TARDBP inclusions, is indicative of disturbed TARDBP function, likely due to disturbances in the ALP or endosomal-lysosomal trafficking in ALS-FTD (Wood et al., 2021). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.