Contrariwise, tipping the scale towards the immunosuppressive phenotype, the use of radiation results most of the time in the direct killing of T lymphocytes inside the radiation field, increments the myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) infiltration, and activates cancer-associated fibroblasts (CAFs) (14) through the TGF-β pathway, therefore, promoting tumor growth (15–17). The gene discussed is TGFB1; the disease is cancer.