classified the iTMEs according to the combined mean density of cytotoxic T cells (CD8+), T regulatory cells (FOXP3+), and immune-checkpoint molecule PD-1 positive cells into: ‘‘inflamed’’ (or ‘‘hot’’), with most immune cells found in the tumor core (TC); ‘‘invasive margin’’ (or ‘‘excluded’’), when most tumor-associated immune cells (TAICs) were found on the invasive margin (IM); and ‘‘desert’’ (or ‘‘cold’’), consisting of samples with very low density in both compartments. The gene discussed is CD8A; the disease is neoplasm.