TGFB1 and cancer: Based on the immune landscape of solid tumors, several pan-cancer classifications were developed: the four consensus molecular subtypes - CMS (ie CMS1 - microsatellite instability immune, CMS2 - canonical, CMS3 - metabolic and CMS4 - mesenchymal) (7), the six immune transcriptomics subtypes – IS (ie wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet and TGF-β dominant) (8) and most recently the four immune/fibrotic TME subtypes (ie IE/F – Immune Enriched/Fibrotic, IE, F, D-Desert) (9).