Results demonstrated that nine genes (PD1, PDL1, CTLA4, PDL2, LAG3, IDO1, B7H3, TIGIT, TIM3) were up-expressed in the high COL10A1 group, which indicates COL10A1 might associate with immune response in BLCA (Figure 8D). This evidence concerns the gene LAG3 and bladder transitional cell carcinoma.