COL10A1 expression was markedly and significantly increased in BLCA (P<0.05, Figures 1A–C), breast invasive carcinoma (BRCA), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), thyroid carcinoma (THCA) and, uterine corpus endometrial carcinoma (UCEC) (P<0.05, Figure 1D). The gene discussed is COL10A1; the disease is rectum adenocarcinoma.